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Additionally, the mean intensity of dihydroethidium (indicative of superoxide levels) was significantly increased in the ganglion cell layer and ONH, and an increased LC3-II to LC1-I ratio suggested an increase in autophagic activity in hypertensive retinas compared to control

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This process is vital for removing harmful substances, including heavy metals, pollutants, and metabolic waste products

A critical insight from this research is the strong correlation between higher dosage regimens and increased prophylactic efficacy

Improvements in some outcomes have been reported, and reviews have concluded that the overall evidence is inconsistent